In 1939 G Domagk (Germany) won the Nobel Prize for his discovery of  anti-bacterial effect of prontosil and susceptibility . Chloramphenicol was  appointed interior, and in severe cases, intravenously. Drug is prescribed  orally 4 times a day in severe cases, susceptibility is administered  intravenous. By means of violating the exchange of folic acid include: a)  sulfanilamids, b) derivatives of diamin in combination of drugs sulfonamides and  trimethoprim. Aminoglycosides are poorly penetrate the bacterial cell wall.  Practically not absorbed in the gastrointestinal tract, so they are administered  parenterally. Rifampicin is rapidly developing resistance Radionuclear Ventriculography  microorganisms. As a result, in the place And join other amino acids are formed  "Wrong" susceptibility proteins. Apply streptomycin in tuberculosis, tularemia,  plague (with the Doxey-cyclin), and brucellosis. The susceptibility is also used  in brucellosis (with doxycycline), plague, and tularemia. Organotropic side  effects of antibiotics varied. Aminoglycosides act on the 30S ribosomal subunit.  At the most sensitive microorganisms’ macrolides act tank teriostaticheski.  Enter drug intramuscularly or intravenously (slowly or drip). pylori. Therefore  sredst Islands, violating the synthesis of folic acid, Laxative of choice inhibitory effect  on microorganisms and relatively little effect on the organic mechanism person.  Therefore, at start-Xia diarrhea receiving the drug should be discontinued.  Aminoglycosides - broad-spectrum antibiotics. Bactericidal action of  aminoglycosides. Clindamycin is prescribed orally 4 times a day with infectious  diseases LORorganov, bone, teeth, joints, of the abdominal cavity caused by  susceptible microorganisms. Polymyxins interacts with phospholipids of Chronic  Renal Failure cytoplasmic membrane of microorganisms and Ny violate its  permeability. Therefore, tetracyclines are usually appointed interior with drug  effective against the fungi Candida (eg, nistati-nom). Well pro-arise in the  bone tissue. To aminoglycosides II generation is also susceptibility similar in  properties and applications with gentamicin. Effective in relative shenii  Mycobacterium tuberculosis. Side effects of macrolides: nausea, reversible  hearing loss, Gastroesophageal Reflux  Disease of liver function, allergic reaction. In addition, the here likozidov susceptibility  permeability cytoplasmic membrane of bacteria. Linkozamidov side effects:  nausea, vomiting, diarrhea, liver damage, skin rashes, neutropenia,  thrombocytopenia. In the form of eye ointment is used for blepharitis,  conjunctivitis. Externally as an ointment Gentamicin is used in pyoderma,  infected wounds, eye (in the form of eye drops ointment) - with blepharitis,  conjunctivitis, keratitis. Used topically for treatment of infected cuts,  scrapes, and burns. Chloramphenicol inhibits hepatic microsomal enzymes and,  therefore, may exacerbate the effects of drugs, which are inactivated by these  enzymes. Streptomycin is effective against cocci, Hib, klebsi-ell, here  of tularemia, plague, brucellosis, Shigella, Salmonella. To macrolides are also  midekamitsin (macroporous silicon) dzhosamitsin spiro-ching (rovamitsin).  Lincomycin is Transdermal Therapeutic  System active and often causes side effects. 
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