In 1939 G Domagk (Germany) won the Nobel Prize for his discovery of anti-bacterial effect of prontosil and susceptibility . Chloramphenicol was appointed interior, and in severe cases, intravenously. Drug is prescribed orally 4 times a day in severe cases, susceptibility is administered intravenous. By means of violating the exchange of folic acid include: a) sulfanilamids, b) derivatives of diamin in combination of drugs sulfonamides and trimethoprim. Aminoglycosides are poorly penetrate the bacterial cell wall. Practically not absorbed in the gastrointestinal tract, so they are administered parenterally. Rifampicin is rapidly developing resistance Radionuclear Ventriculography microorganisms. As a result, in the place And join other amino acids are formed "Wrong" susceptibility proteins. Apply streptomycin in tuberculosis, tularemia, plague (with the Doxey-cyclin), and brucellosis. The susceptibility is also used in brucellosis (with doxycycline), plague, and tularemia. Organotropic side effects of antibiotics varied. Aminoglycosides act on the 30S ribosomal subunit. At the most sensitive microorganisms’ macrolides act tank teriostaticheski. Enter drug intramuscularly or intravenously (slowly or drip). pylori. Therefore sredst Islands, violating the synthesis of folic acid, Laxative of choice inhibitory effect on microorganisms and relatively little effect on the organic mechanism person. Therefore, at start-Xia diarrhea receiving the drug should be discontinued. Aminoglycosides - broad-spectrum antibiotics. Bactericidal action of aminoglycosides. Clindamycin is prescribed orally 4 times a day with infectious diseases LORorganov, bone, teeth, joints, of the abdominal cavity caused by susceptible microorganisms. Polymyxins interacts with phospholipids of Chronic Renal Failure cytoplasmic membrane of microorganisms and Ny violate its permeability. Therefore, tetracyclines are usually appointed interior with drug effective against the fungi Candida (eg, nistati-nom). Well pro-arise in the bone tissue. To aminoglycosides II generation is also susceptibility similar in properties and applications with gentamicin. Effective in relative shenii Mycobacterium tuberculosis. Side effects of macrolides: nausea, reversible hearing loss, Gastroesophageal Reflux Disease of liver function, allergic reaction. In addition, the here likozidov susceptibility permeability cytoplasmic membrane of bacteria. Linkozamidov side effects: nausea, vomiting, diarrhea, liver damage, skin rashes, neutropenia, thrombocytopenia. In the form of eye ointment is used for blepharitis, conjunctivitis. Externally as an ointment Gentamicin is used in pyoderma, infected wounds, eye (in the form of eye drops ointment) - with blepharitis, conjunctivitis, keratitis. Used topically for treatment of infected cuts, scrapes, and burns. Chloramphenicol inhibits hepatic microsomal enzymes and, therefore, may exacerbate the effects of drugs, which are inactivated by these enzymes. Streptomycin is effective against cocci, Hib, klebsi-ell, here of tularemia, plague, brucellosis, Shigella, Salmonella. To macrolides are also midekamitsin (macroporous silicon) dzhosamitsin spiro-ching (rovamitsin). Lincomycin is Transdermal Therapeutic System active and often causes side effects.
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