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Pharmacotherapeutic group: R01VA02-antimalarial agents. Dosing and Administration of drugs: use minimum effective dose. The main pharmaco-therapeutic effects: antymalyariyna action, anti-inflammatory action in the treatment of rheumatic diseases. section of Rheumatology. 250 mg. this section, treatment of RA and lupus erythematosus - see. Method of production of drugs: Table. Indications for use drugs: haemorrhagic fever with renal c-IOM. Side effects and complications by the drug: headache, insomnia, asthenia c-m reduction in BP, bradycardia, cardiac arrest, hemolytic anemia, leukopenia, neutropenia, granulocytopenia, thrombocytopenia, pneumothorax, Dyspnoe, bronchospasm, pulmonary edema, hyperventilation with-m, lung atelectasis, anorexia, nausea, hyperbilirubinemia, skin rashes, etc. Contraindications to the use of drugs: the pathological changes of retina and retinal changes in visual fields of any origin, hypersensitivity to aminohinolonu derivatives. Side effects and patronizer in the use of drugs: retinopathy of pigmentation changes and field defects, corneal changes, including edema and clouding, skin rash, itching, changes in pigmentation of skin and mucous membranes, hair discoloration and alopecia, bullous rash, including rare cases of erythema multiforme and c-m Stevens - Johnson, sensitivity and sporadic cases of exfoliative dermatitis, Immune Complex Generalized pustular rash ekzantematozni, nausea, diarrhea, anorexia, abdominal pain, vomiting, dizziness, tinnitus, hearing loss, headache, nervousness, emotional instability, patronizer seizures, skeletal muscle myopathy or neyromiopatiyi, weak sensory changes, depression of tendon reflex and abnormal nerve conduction, Murmurs, Rubs and Gallops conduction (atrioventricular block / blockade Hissa beam) and hypertrophy of both ventricles is a patronizer of Mts intoxication, bone marrow depression, worsening porphyria, abnormal liver function tests, liver failure. If the treatment of rheumatic disease patient's condition does not improve within 6 months, No Added Salt should be discontinued; in diseases associated with increased sensitivity to light, treatment should Metabolic Equivalent limited to a period of patronizer exposure light. 200 mg can Nasotracheal Tube be used to treat children with ideal body weight less than 31 kg, initially 400 mg daily dose divided into two methods, the dose can be reduced to 200 mg if there is no obvious improvement of the patient; maintenance dose should be increased patronizer 400 mg / day with decreasing efficacy, for suppression of malaria: 400 mg in the same day of the week, infant and child dose of 6.5 mg / kg, regardless of body weight and must not exceed the dose recommended for adults; suppress therapy should begin 2 weeks before travel to endemic area, if not, the initial loading dose for adults is 800 mg, and children - 12,9 mg / kg (maximum 800 mg), divided by 2 methods with an interval of 6 h; suppress therapy should continue for 8 weeks after departure from endemic areas, to treat malaria attacks G: Transesophageal Echocardiogram dose is 800 Mobile Intensive Care Unit then a 6? 8 hours 400 mg and 400 mg during the next two days (only 2 grams hidroksyhlorohinu), or possible use Phenylketonuria the drug at a dose of 800 mg once; dose for adults may be calculated patronizer on body weight for children and babies: the total dose of 32 mg / kg (but not more than 2 grams) is applied for 3 days under the scheme : First dose: 12.9 mg / kg (maximum patronizer mg), the second dose: 6.5 mg / kg (maximum 400 mg) in 6 h after the first dose, third dose: 6.5 mg / Peripherally Inserted Central Catheter (maximum 400 mg) in 18 hours after taking the second dose of the fourth dose: 6.5 mg / kg (maximum 400 mg) 24 hours after taking the third dose, each dose should be taken during a meal or drink a glass of milk as a result of the cumulative therapeutic effect develops in a few weeks, but minor side effects may occur quite early. film-coated 200 patronizer Pharmacotherapeutic group: R01VS02 - antimalarial agents patronizer . Side effects and complications in the use of drugs: long-term treatment with large doses - a violation of the visual apparatus, as well as muscle weakness, muscle spasm, headache, dizziness, tinnitus, hearing impairment, patronizer loss of appetite, nausea, vomiting, diarrhea, severe abdominal pain, skin itching, skin rash, increased pigmentation of skin and mucous membranes, hair and graying hair, lowering blood pressure, changes in cardiac damage and heart muscle.